Cell-in-Cell Death Is Not Restricted by Caspase-3 Deficiency in MCF-7 Cells
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چکیده
منابع مشابه
Cell-in-Cell Death Is Not Restricted by Caspase-3 Deficiency in MCF-7 Cells
PURPOSE Cell-in-cell structures are created by one living cell entering another homotypic or heterotypic living cell, which usually leads to the death of the internalized cell, specifically through caspase-dependent cell death (emperitosis) or lysosome-dependent cell death (entosis). Although entosis has attracted great attention, its occurrence is controversial, because one cell line used in i...
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Caspase-3 plays a critical role in a proteolytic cascade within the apoptosis signal pathway; this enzyme is commonly activated by numerous death signals and cleaves a variety of important cellular proteins. Using caspase-3-deficient MCF7 cells and clones stably transfected with the caspase-3 gene (MCF7/Casp3), we evaluated the role of caspase-3 in Bax-induced apoptosis. Bax overexpression indu...
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Objective(s): Breast cancer is a devastating disease related to women. The anticancer properties of 8-hydroxyquinoline (8HQ) and the increasing use of graphene oxide (GO), as a drug delivery system with anti-cancerous properties, led us to investigate the toxicity and apoptosis-induction capability of 8HQ-coated GO on breast cancer cells compared with normal breast cel...
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ژورنال
عنوان ژورنال: Journal of Breast Cancer
سال: 2016
ISSN: 1738-6756,2092-9900
DOI: 10.4048/jbc.2016.19.3.231